Myenteric and submucous plexus inhibitory abnormality is termed as neuronal intestinal dysplasia (NID). The uncommon NID type A is a sympathetic nervous system condition that typically causes obstructive symptoms, bloody and mucusy diarrhoea, and sporadically, colon perforation. It is necessary to perform a colostomy and to have the afflicted intestinal segment removed. Submucous plexus hyperplasia is a feature of type B. Prominent pathologists have standardised the biopsy procedure and evaluation standards, and histochemical features have been morphometrically analysed. After histotopochemical tests for acetylcholinesterase & lactate or succinate dehydrogenase, the diagnosis is made by examining mucosal samples. Despite nearly identical clinical symptoms, there may be variable degrees of histochemical involvement.
In general, a treatment of conservative therapy must be made for at least six months because development of the propulsion activity is conceivable in all types. 90% of the time, posterior sphincteromyotomy is successful in treating persistent faecal retention without internal sphincter relaxation. Resection of the rectum & descending colon is necessary for patients who have severe rectal dilatation but no propulsion since rectosigmoidectomy has a high recurrence rate. A specific work-up & set of indications are necessary for the treatment in aganglionosis when it coexists with NID.