The full form of LAD in Medical is Leukocyte Adhesions Deficiency. It is a special type of syndrome occurring in a group of rare disorders. In this syndrome, a person’s immune system is the main target.
These syndromes are identified by defects that determine how white blood cells travel to and respond to the site of infection or injury. However, the severity and major symptoms of LAD syndrome vary from person to person.
A person with LAD may experience an enhanced susceptibility to fungal and bacterial infections. Other signs may appear depending on the specific subtype.
What causes LAD in humans is the mutation of certain genes that contain instructions for making specific proteins that are important for white blood cells to move from the bloodstream to the location of inflammation or infection. People who have a severe form of LAD may be deficient in such proteins. In milder forms of LAD, the levels of such proteins may be low. Additionally, they may have retained some residual protein activity.